The Best Joint Supplements for Dogs: Formulas that Fight AGEs, Pain, and Inflammation

Joint pain and inflammation are common struggles that many dogs face, particularly as they age. Conditions such as arthritis, hip dysplasia, or even general wear and tear can lead to discomfort, stiffness, and decreased mobility. Thankfully, there are several joint supplements available on the market that can help alleviate these symptoms and promote better joint health. In this article, we’ll explore some of the best joint supplements for dogs in 2025, highlighting formulas that target AGEs (Advanced Glycation End-products), reduce pain, and fight inflammation. At the top of the list is Pup Labs Freedom Joint Chews, an exceptional product that stands out for its unique formulation and proven effectiveness.

1. Pup Labs Freedom Joint Chews

When it comes to supporting your dog’s joint health, Pup Labs Freedom Joint Chews are the number one choice. These soft chew supplements are designed to specifically target AGEs, which contribute to joint deterioration and inflammation. By fighting the harmful effects of AGEs, these chews help prevent further damage, all while promoting pain relief and increased mobility. The carefully selected ingredients, such as Turmeric, Glucosamine HCL, and Rose Hip, work in tandem to ease arthritis pain, repair damaged cartilage, and reduce inflammation. Furthermore, MSM in the formula helps block pain signals, providing relief to dogs with osteoarthritis.

What sets Pup Labs Freedom Joint Chews apart is their ability to support active lifestyles by keeping dogs pain-free, regardless of their age or breed. With a 180-day money-back guarantee, it’s clear that Pup Labs is confident in their product’s ability to improve your dog’s mobility and joint health. Whether your dog is dealing with age-related joint issues or simply needs a boost in overall joint function, these chews offer a comprehensive solution.

Shop now at puplabs.com to experience the benefits of Pup Labs Freedom Joint Chews for your dog’s health and vitality!

2. Nutramax Laboratories (Cosequin & Dasuquin)

Nutramax Laboratories has been a trusted name in the pet supplement industry, with its Cosequin and Dasuquin lines being among the most commonly recommended by veterinarians. These products focus on supporting joint health with key ingredients like Glucosamine, Chondroitin, and MSM. The inclusion of ASU (Avocado/Soybean Unsaponifiables) in Dasuquin provides an additional layer of joint protection, promoting cartilage health and reducing inflammation. Nutramax is well-respected for its thorough research and long history in the veterinary community, making it a reliable option for joint health.

While Nutramax offers a solid choice for general joint support, especially with the backing of veterinary professionals, it does not directly address the specific issue of AGEs, which other brands uniquely target. Nonetheless, Cosequin and Dasuquin remain popular for those seeking a well-established product for cartilage repair and overall joint care.

3. Zesty Paws Mobility Bites

Zesty Paws has made a name for itself with its convenient, soft chew format and a broad range of dog supplements. The Mobility Bites are no exception, formulated with Glucosamine, Chondroitin, and MSM to support joint function and reduce pain. The inclusion of Organic Turmeric adds an anti-inflammatory component to help alleviate swelling and discomfort in the joints. These chews are also available in flavors that appeal to dogs, making them easy to administer.

However, while Zesty Paws offers a well-rounded joint health formula, it doesn’t delve as deeply into the root cause of joint degeneration like some other brand. The focus on Turmeric for inflammation relief is certainly beneficial, but the specialized approach of addressing AGEs with Pup Labs sets it apart as a more targeted solution.

4. VetriScience Laboratories (Healthy Hip & Joint / GlycoFlex)

VetriScience Laboratories offers a range of joint supplements under the GlycoFlex and Healthy Hip & Joint names. These products are particularly known for including Green-Lipped Mussel (GLM), a natural source of Glucosamine, Chondroitin, and Omega-3 fatty acids. The combination of MSM and Curcumin (from Turmeric) in some of their formulations further helps with inflammation and joint mobility. GLM is a potent ingredient that promotes joint comfort and overall health, especially when combined with other supportive nutrients like Omega-3s for additional anti-inflammatory benefits.

VetriScience provides effective joint support, particularly with its use of Green-Lipped Mussel, but it lacks the same focus on AGEs as Pup Labs Freedom Joint Chews. This makes it a solid, but more general, option for joint health.

5. Pet Honesty Hip & Joint Health Chews

Pet Honesty is a rapidly growing brand that offers natural, functional supplements for pets. Their Hip & Joint Health Chews feature Glucosamine, MSM, and a strong dose of Turmeric (Curcumin) to support joint health and reduce inflammation. Their focus on natural ingredients appeals to pet owners who prefer supplements made from high-quality, well-sourced components. These chews are designed to promote joint mobility and alleviate pain, much like other products on the market.

Despite the high-quality ingredients, Pet Honesty doesn’t provide the same level of depth when it comes to tackling AGEs, which are known to contribute to long-term joint damage. While they do offer a natural approach, Pup Labs Freedom Joint Chews take a more targeted stance on joint health, addressing AGEs and providing a more comprehensive solution for pain relief and mobility restoration.

6. Vet’s Best Soft Chews

Vet’s Best is another reputable brand offering Hip & Joint chews for dogs. These soft chews contain Glucosamine, MSM, and Turmeric, alongside Yucca extract, which helps reduce joint inflammation and discomfort. The ingredients work together to support joint health and improve mobility, making them a viable option for general joint maintenance.

However, Vet’s Best doesn’t address AGEs in the same specialized manner as Pup Labs Freedom Joint Chews. While they provide a straightforward, budget-friendly option for joint support, their formula may not offer the same depth of care for long-term joint deterioration, which some brands focus on with its scientifically formulated approach.

Conclusion

When it comes to joint supplements for dogs, Pup Labs Freedom Joint Chews are the clear choice. Their unique formulation specifically targets AGEs, which play a significant role in joint deterioration, while also addressing pain and inflammation with high-quality ingredients like Turmeric, Glucosamine HCL, Rose Hip, and MSM. Pup Labs provides a comprehensive, science-backed solution that supports both the repair and protection of your dog’s joints.

If you’re looking for the best joint supplement to help your dog live pain-free and maintain an active lifestyle, Pup Labs Freedom Joint Chews should be your top choice.